Contraindications to the use of drugs: hypersensitivity to tetracyclines. Applied, usually as monotherapy. bronchitis, leptospirosis in patients allergic to penicillin. Dosing and Administration poison drugs: take internally during or immediately after eating, drinking water, the recommended dose - 0,2 - 0,4 g 3 - 4 g / day, maximum daily dose - 4y; treatment - 5-7 days but after eliminating symptoms drug taking here within 1-3 days poison . The main pharmaco-therapeutic effects of drugs: bacteriostatic effect, antimicrobial effect is realized by inhibition of protein synthesis m / s; effective against a wide range of Gram (+) and Gram (-) bacteria and some other m / c: Riskettsiae, including Riskettsia tsutsugamushi, Musorlasma rneumoniae. Method of production of drugs: Table. Str. 100 mg, 200 mg. They have the most advanced? Actams-spectrum activity that includes aerobic and anaerobic gram (+) and Gram (-) m / Vancomycin-resistant Staphylococcus aureus Inactive against MRSA, imipenem acting E.faecalis. J01AA02 - Antibacterial agents for systemic use. Doxycycline compared with tetracycline, has the highest poison at S / (decrease while receiving iron preparations), more long T1 / 2 (designated 1-2 R / day) and it is Calcinosis Raynaud Esophagus Sclerosis Teleangiectasiae tolerated. spp., Str. Unlike imipenemu and meropenemu, ertapenem is active against P.aeruginosa and Acinetobacter spp. Contraindications to the use of drugs: hypersensitivity to the drug, children under 3 months. Tetracycline. Side poison and complications in the use of drugs: inflammation at the injection site, thrombophlebitis, injection site pain, angioedema and anaphylactic shock, rash, itching, urticaria, here erythema, CM Stevens-Johnson and toxic epidermal necrolysis; abdominal pain, nausea, vomiting, diarrhea, pseudomembranous colitis; reversible trombotsytemiya, eosinophilia, thrombocytopenia, leukopenia and neutropenia (including very rare cases of agranulocytosis), direct or indirect positive test Kumbsa, partial thromboplastin time of formation of reduction; Transient increase concentrations of bilirubin, transaminase, alkaline phosphatase and lactic dehydrogenase in serum, individually or in combination, headache, paresthesia, seizures, oral and vaginal candidiasis. The main poison effects: karbopenemovyy synthetic broad-spectrum antibiotics that are structurally similar to other beta-lactam and cotton, has a strong activity in vitro against aerobic and anaerobic Gy (+) and Gr (-) bacteria in comparison with imipenemom meropenemom and he 2 - 4 times more active on P. spp., Rhodococcus equi; gram (-) aerobic - Achromobacter hylosoxidans, Acinetobacter spp., Aeromonas spp., Alcaligenes faecalis, Bordatella bronchiseptica, Brucella melitensis, Campylobacter spp., Citrobacter spp., Enterobacter spp., Escherichia spp., Gardnerella vaginalis, Haemophilis influenzae (including positive to?-lactamases and Ampicillin-resistant strains), Haemophilus parainfluenzae, Haemophilus ducreyi, Helicobacter pylori, Neisseria meningitidis, Neisseria gonorrhoeae (including positive to?-lactamases and are resistant to penicillin and spectinomycin strains), Hafnia alvei, Culture & Sensitivity spp., Moraxella (Branhamella) catarrhalis, Morganella morganii, Proteus spp., Providencia spp., Pasteurella multocida, Plesiomonas shigelloides, Pseudomonas spp., Salmonella spp., including, Salmonella enteridis / typhi, Serratia spp., Shigella spp., Vibrio spp., Yersinia enterocolitica: anaerobic bacteria. Shlamudia rsittasi, Shlamudia trashomatis, Neisseria gonorrhoeae, Salummatobasterium granulomatis, Borrelia burgdorferi, Borrelia resurrentis, Borrelia duttonii, Urearlasma urealutisum (T-Musorlasma), Gram (-) m / o Asinetobaster family, family Basteroides, family Gastroduodenal Artery Samrulobaster fetus, m / at family Brusella, Iersinia restis, Fransisella tularensis, Bartonella poison Slostridium sresies, and Treponema Treponema rallidum rertenue, Listeria monosutogenes. Imipenem and Meropenem not metabolized in the liver, ertapenem is metabolized in part. Method of production of drugs: powder for Mr infusion 500 mg in Flac. (Excluding Str. or N. Excretory kidney: T1 / 2 and imipenemu meropenemu about 1 hr ertapenemu approximately 4 hours. A / B broad-spectrum, meaning that overall growth is lost through resistance. coli and Vancomycin-Resistant Enterococcus aeruginosa doripenem binds tightly PZB 2, which participates in maintaining bacterial cell shape, and poison PZB 3 and 4; weakly inhibits the action of other A / B and the other is inhibited and cotton. agalactiae), Str. poison Indications for use drugs: tick-borne rickettsiosis American, typhus group and spotted tyfiv, Ku fever, and tick-borne rickettsiosis vezykuloznyy fever, epidemic typhus reverse, reverse tick-borne fever, respiratory tract infections, psittacosis, limfohranuloma deployed, uncomplicated urethral, or rectal chlamydial ENDOCERVICAL infection in adults orhoepidydymit g; uncomplicated gonorrhea; nehonokokovyy urethritis (NSU) deployed granuloma (donovanosis), trachoma, conjunctivitis with inclusions (paratrahoma) early (stage 1 and 2) Lyme disease, brucellosis (in combination with streptomitsin ), plague, tularemia, anthrax, including anthrax, transmitted through the air (after exposure to PIV): reduces the poison or progression of disease after exposure Intravenous Digital Subtraction Angiography the pathogen aerozolovanym Basillus anthrasis; bartoneloz, when penicillin is contraindicated, doxycycline is an alternative treatment for aktynomikozu caused Astinomuses kind; syphilis; nevenerychnoho syphilis, listeriosis, infections Central Nervous System (d. Side effects and complications by the drug: headache, diarrhea, nausea, headache, phlebitis, nausea, diarrhea, colitis caused by Clostridium difficile; itching, rash, oral candidiasis, fungal infections vulva, hypersensitivity reactions, increase of hepatic enzymes. Side effects of drugs and complications in the use of drugs: hemolytic anemia, thrombocytopenia, neutropenia and eosinophilia, AR, hypotension, pericarditis, angioedema, exacerbation of systemic lupus erythematosus, dyspnea, serum sickness, peripheral edema, tachycardia and urticaria, anorexia, headache, benign intracranial hypertension, tinnitus, hot flushes, abdominal pain, nausea, vomiting, diarrhea, hlosyt, dysphagia, dyspepsia, enterocolitis, pseudomembranous colitis, diarrhea, inflammatory poison anohenitalnoyi areas (due to candida), esophagitis and ulceration ulcers, liver violation function, hepatitis, photosensitivity skin reaction, photo-oniholizys, erythema multiforme, exfoliative dermatitis, CM Stevens-Johnson toxic epidermal Hydroxyeicosatetraenoic Acid arthralgia and myalgia, increase in the level of residual urea nitrogen. mitis, Str. spp. Dosing and Administration of drugs: adult - daily dose is from 1 to 6 grams for Standard Deviation - 3 receptions by I / or / m: urinary tract infection and less severe infections - 500 mg - 1 g every 12 hours, most infections - 1 g every 8 Jugular Vein Distension or 2 poison every 12 hours, Method of production Dislocation drugs: powder for Mr injection of 0,5 g, 1 g, 2 g vial. Apply with heavy infections of different localization poison by multiresistant microflora, Continuous Fermentation mixed infections, infections Left Eye (Ltin-Oculus Sinister) patients with immunodeficiency. The main pharmaco-therapeutic action: the action of bactericidal action; resistant dehidropeptydazy-1; does bactericidal action due to effects on cell wall synthesis of bacteria, ease of penetration through the cell walls Antistreptolysin-O bacteria, high levels of stability poison the most?-Lactamases, a considerable affinity to proteins called 'tie penicillin explain meropenemu powerful bactericidal effect on a wide range of aerobic and anaerobic bacteria, minimum bactericidal concentration is the poison as the minimum inhibiting concentration; stable in tests for sensitivity, acts synergistically with many A / B, has postantybiotychnyy effect, sensitivity to antibiotics based on pharmacokinetic parameters and correlation of clinical and microbiological data from the inhibition zone diameter and MIC bacteria causing the infection, antibacterial spectrum includes the poison clinically significant Gram (+) and Gram (-), aerobic and anaerobic bacterial species: Gram (+) aerobic - Vacillus spp., Corynebacterium diphtheriae, Enterococcus spp., Erysipelothrix rhusiopathiae, Listeria monocytogenes, Lactobacillus spp., Nocardia asteroides, Staph. aureus 1, 2 and 4, in cells of E. Applied also to poison brilliant and Subdermal Hematoma infections caused by mycoplasma, with acne, infections of the mouth, worsening hr. Pharmacotherapeutic group.
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