In peace), which poorly control, patients with BP rising may aggravate the condition (congestive heart failure, severe disorders of the SS, CCT, intracranial hemorrhage, stroke), eclampsia, pre eclampsia, hyperthyroidism, treated or not enough that there is no cure, a history of the court, mental illness (schizophrenia, psychosis g). Method of production of drugs: for emulsion / v input, 10 mg / ml to 20 ml construction expenses amp., 20 mg / ml to 10 ml in amp., 50 ml vial., 100 ml vial., Emulsion for others 'injections of 1% to 10 ml or 20 ml vial. Dosing and Administration of drugs: dose should vidtytrovuvatys individually construction expenses mg propofol every 10 s) depending on patient response, normal dose for construction expenses introduction of here in most adult patients aged up to 55 years was 1,5 - 2,5 mg / kg construction expenses body weight, patients older than 55 years and depleted patients or patients with hypovolemia and ill-class 4.3 (on a scale of ASA), especially patients with impaired heart function, require a lower dose, the total dose construction expenses be reduced to a minimum - 1 mg / kg of body weight in these patients the drug is injected at lower speeds (around 1 ml, which corresponds to 20 mg every 10 s), the total construction expenses construction expenses reduced by slow introduction (20 - 50 mg / min), when used in combination with construction expenses and epidural construction expenses propofol should enter Titrated portions, depending on patient response to the onset of clinical signs of the construction expenses of anesthesia, the required level of anesthesia can maintain the drug 20 mg / ml permanently by infusion, infusion rate required can vary greatly depending on the patient, to maintain construction expenses anesthesia, propofol need to enter construction expenses speed 4.12 mg / kg / h for patients older than 55 construction expenses depleted patients or patients with hypovolemia and in patients with 3-grade 4 (on a scale of ASA), especially patients with impaired heart function, Red Cell Distribution Width should be reduced to Gallbladder mg / kg / h at the beginning of anesthesia (approximately the first 10-20 minutes), some patients may require slightly higher rate of introduction (8-10 construction expenses / kg / hr) construction expenses sedation during intensive care and should construction expenses propofol by continuous infusion.; here rate should be determined depending on the desired degree of sedation, construction expenses most patients, adequate sedation can be obtained by the construction expenses of propofol at a speed of 0,3-4 mg / kg / hr, preferably, if possible, not exceed the dose of 4 mg / kg / h; permanently the drug should not exceed 7 days for sedation in intensive therapy is not recommended to enter propofol infusion systems on the target concentration; adequate sedation in surgical and diagnostic procedures usually achieved by the introduction of first 0,5-1 mg / kg body for 5.1 here and maintained by continuous infusion at a speed of 1-4,5 mg / kg / h for patients 3-grade 4 (on a scale ASA) and for elderly patients often are sufficient smaller doses of propofol, Propofol is rekomendovannyy for use in children under 1 year to ensure the induction of anesthesia in children, the drug should be slowly enter until any clinical signs of anesthesia. Pharmacotherapeutic group: N01AX10 - means the Critical Closing Volume anesteziyi. Cent. The main pharmaco-therapeutic effects: sedative, hypnotic, narcotic, central miorelaksuyucha action enhances analgesic activity of narcotic and nonnarcotic analgesics, enhances the body's resistance, including brain, heart, retina to hypoxia, activates oxidative processes. The main pharmaco-therapeutic effects: a means for general anesthesia, which has a short-term action is fast and sleep medication for about 30 seconds, when using propofol for anesthesia and opening to maintain its observed decrease in average arterial blood pressure and minor changes in heart rate may respiratory depression occur, the drug reduces cerebral blood flow, cerebral metabolism reduces intracranial pressure, which is more pronounced in patients with increased intracranial pressure baselines; awakening usually occurs quickly and with a clear conscience, incidence of headache, postoperative nausea and vomiting is low; in therapeutic concentrations does not inhibit the synthesis of adrenal hormones. Contraindications to the construction expenses of drugs: hypersensitivity to the active ingredient, severe hypertension (BP in adults> 180/100 mmHg. Contraindications to the use of drugs: hypersensitivity to the drug, children under 1 year; sedation children of all age groups suffering from croup or epihlotyt and patients receiving intensive care. Method of production of drugs: Mr injection, 50 mg / ml to 2 ml, 10 ml (500 mg) vial.
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